possible nature cancer

However we still are unable to understand the origin of cancer completely, everyone knows that one of the aspects of a cancer cell is its change from differentiation into dedifferentiation.

In 1981 I suggested in an article concerning cancer that one of the aspects of a differentiated cell could be a cell specific hyaluronidase, a nutrimental enzyme that is synthesized by every cell. (1)
Due to a long-lasting clinical study with the use of embryonic cells, it became clear that this previous hypothesis was reality. (6)
The essences of hyaluronidase in direct relation to cell nutrition and indirectly to its mitosis was already published in some other articles. (3,4,5)
Due to these clinically proved hypotheses, perhaps the insights about the origin of cancer can find progress.

The selected nutrient supply and waste production of differentiated cells

In 1979 I presented an article about the cellular unit: the cell together with its interstitial groundsubstance and/or the muco-polysaccharide layer together with the cellular enzyme hyaluronidase. This "cellular atmosphere" is the product of its own metabolism. It is the waste product of its metabolism. This enzyme dissolves this waste product and so the cell can regulate its nutrient supply itself. And by regulating its own nutrient supply it regulates also its cell activity and its mitotic rate. A failure of this enzyme (pH changes) was stated theoretically to be the cause of irreversible shock and multiple organ failures. (3) Clinical experimental treatments made clear that this theory was correct.

In 1980 an article was submitted concerning placental hyaluronidase in relation to fetal growth. In this article it was suggested that juvenile pulmonary distress syndrome was equal to irreversible shock in adults and that this illness -that merely originates in premature delivery- was the cause of an acute fall of placental hyaluronidase. (4) Clinical experimental treatments with placental extracts also proved this theory.(8) As this placental hyaluronidase not only circulates in the new born blood circulation but also in the maternal one, the increase nutrient supply necessary for this fetal growth could easily be explained. Then the postnatal depression could be the result of the acute fall in general energy supply as well. With this knowledge hundreds of patients suffering postnatal depression were treated during several years. (6)

And finally a hypothesis of the cause of cell dedifferentiation and "explosive" mitosis was presented in 1981. (2) In this article it was stated that every specialized cell produces a cell specific hyaluronidase in order to dissolve its own specific waste layer of mucopolysaccharides. In other words: It was stated that specific hyalurunidases were bounded to specific cell functions. That means: It was hypothesized, that omnipotent cells produce omnipotent qualities of hyaluronidases and that all different hyaluronidases only dissolve the mucopolysaccharides of their own specific organ. Because the placenta is developed in the very early phase of pregnancy this enzyme-complex is an omnipotent one that induces by injection also a general increased nutrient supply to all body cells: resulting in "revitalization". By injecting other organ extracts this than would lead to a revitalization of the corresponding organ only. This is the basic explanation how the so-called cell therapy of Niehans works. (6) With this therapy I worked several years and treated hundreds of patients by general revitalization or locally. However I never can state definitively that this therapy was only based on this underlying theory, the results were so obvious that this theory for me was a valid one. This theory is even more interesting for the insights about dedifferentiated cells than it is for differentiated ones, because…

For differentiated cells this implies that all different cells do have a different cellular ground substance. This seems very logical because they also do have a specialized metabolism. That also implies that every specialized cell do have its own waste dissolving mechanism. This implies that the diffusion of blood samples through this cell layer is a different one as well. Then this means that they all there own "filter system", due to which they all receive only nutrients that they need for their cell specific function. Due to this cell specific "filter system" this automatically implies that other cells with other filter systems e.g. nutrient use, never can survive in other organs. In there they miss the basic trigger for their own metabolic activity.

With this suggested theory it also can be explained easily why specific organs show a higher activity when one specific product increases in the circulation. The best example for it is the pancreas in relation to glucose.

Finally it also means that the organs in our body- independently from brain activities- can have the possibility to increase or decrease its metabolic rate as well. During this increased metabolism the mitotic rate increases also and decreases again by a decrease of this special product. When this product stay increased ,slowly this organ will become bigger as well. This explains also our evolutionary process.

The "general" nutrient supply to undifferentiated cells.

The difference between differentiated and undifferentiated cells is that the latest one does have more than one function. This implies that these cells make more than one type on hyaluronidase. In case of cancer this increased quantity of hyaluronidase has been found to be increased. This is also the reason that the mitotic rate increases as well. But mitosis increases much more explosive than in differentiated cells because…. When we look into a factory the nutrients can be divided into general and specific "nutrients". So each specific hyaluronidase regulates both. In case of dedifferentiation the general nutrient supply increases much more than in case of differentiated cells. Wasn't differentiation induced due to starvation only? (4). Is that the explanation for the explosive increased mitosis? It can be, but it still don't give an answer how and why the dedifferentiation originates.

The possible move to dedifferentiation.

About 20 years I worked on this "groundsubstance" level: the cellular atmosphere. More and more I became amazed how huge the resemblance was between our body and all nature in general. Nature with all different life species, pregnancy as being a rapid film of the whole evolutionary process, the specialists in our society as being also the result of a fight in order to survive. Isn't it amazing?

In nature -like in the cell- specific species that stay alive with specific nutrients and general ones in order to survive. In nature where species grow in amount when the specific nutrients increase. In nature in which the waste products also play such an important role. The more I discovered the more resemblance seemed to appear.

After the specific waste layers of specific cells are dissolved by the cell specific hyaluronidases, they the diffuse in the blood circulation .It's like in nature these waste products "diffuse" in the environment as well. Should these waste products trigger -like in nature- other organs in their activity? Can you understand my astonishment reading in the wisdom of acupuncture about this phenomenon?

During about 7 years I measured with electro-acupuncture of Voll and finally I found what has been described already ± 5000 years ago precisely.

In our vision of nature we know that waste is dangerous for the specimen that produce this waste. Could this be also the case for specialized cells? In nature cancer don't exists even like illnesses in general. Was it a coincidence only that I had to use always hypothalamus and corpus callosum hyaluronidases in order to rebalance the imbalanced organ activities? Both brain parts form more or less a bridge between the left and right brain. We became so strong in our survival force only because of our thinking. Was there a relation between illness occurrence and thinking?

Recently I presented an article about our genes and gene changes due to attractive and repulsive emotions during cell mitosis. In there I postponed the theory that these emotions alter the organ activities in respectively increased and decreased organ activity as well as how these changes are hereditive ones as well. (7) Was this the reason that I found with electro-acupuncture measurements such a chaos in the collaboration between all organs?

Let me go back now I go back to the consequences of these imbalances in relation to waste production of all different organs.

An organ that has a higher activity produces more waste than organs with low activity. This waste can not be recycled anymore by a "natural" increased activity because the energy supply is "blocked" genetically. Then these organs only can only increase activity without receiving more energy. Then the "overwork" themselves. And that's what one can measure with this method.

And like in man this overwork finally leads to the well known "burnout syndrome": also in the cell. These organs are primarily very sensitive for infections. And, at the moment that they slow down there functions they also not react anymore on the "waste trigger" of its specific "co-partner". And at that moment the waste producer comes in a real problem. This waste then irritates its cells and due to this irritation the blood supply increases even more. And finally this over-energy gives this organ the power to dedifferentiate its function by stimulation of the slumbering rest-function from its evolutionary development (pregnancy). And the trigger is exactly the one that once created a whole organ to clean the "body nature" of waste. In here I will give you one example: In this "natural" play of waste the liver reacts with an increase of activity when the lung activity increases. This can be provoked easily by smoking a cigarette. For all organs another one react on this increased waste. In all books about the underlying knowledge about acupuncture this is described precisely. At the moment that in our case the liver fall in a state of "burnout" the lung reacts with hepatisation of its cells. This is very well described in pathology books in case of lung cancer.

However I found this same mechanism in many sorts of cancer -using the old wisdom- it is very hard to prove it also as being the only cause.
By my knowledge concerning evolution it seems to obvious that every organ that require genetically an abundance of energy during a long time -even over generations finally find the way back of this evolutionary process. The way back because evolution was induced only by a constant adaptation to the lack of energy .
But because the quantity of species in nature is very well controlled I am sure, that firstly our thinking and secondly waste is the final trigger for the development of cancer.

Final comments

Nature and mankind? Again I was astonished. Don't we recycle our own waste in order to keep ourselves alive? And isn't it amazing that scientists recently found in waste belts of old cultures that they all stated recycling just before they disappeared? Was cancer in man at these times also present? I

Personally I could not find it, but the acupuncture-wisdom described this illness also precisely. They called it the circle of contempt of the inner cycle of life (the waste cycle). I "re"-searched a very old wisdom. Due to that I know now that cancer is a natural reactive mechanism in order to survive and nothing more.

I realize very well that I was only a clinician who experimented with different types of hyaluronidases directly on my fellowman. As being a clinician I never saw genes like they can be visualized in the laboratories. But the findings in laboratories are fixed observations only. In contrast this electro-acupuncture method shows alive pictures. Individually none of them never will find the real genesis of cancer. The only way is the way of collaboration. Due to that I only can hope that -however e.g. electro-acupuncture till now did not receive admission- that new ideas are not directly condemned as being nonsense.

We still are a product of all nature and history learned us as well that only collaboration can bring us further. Wasn't this also the way of our evolutionary process? It all seems very plausible that our unnatural attitude is the cause of all our troubles and nothing more.

References
1. Bok-S.W. Hyaluronidase, from wound healing to cancer. Med-Hypotheses 1981; 7: 1147-56.
2. Bok-S.W. Hyaluronidase, from wound healing to cancer 2.Med-Hypotheses 1982; 8: 445-448.
3. Bok-S.W. The fundamental role of hyaluronidase in tissue. Med-Hypotheses 1979; 5: 1183-200
4. Bok-SW. Hyaluronidase, the fundamental cause of foetal growth. Med. Hypotheses 1980; 1087-96.
5. Bok.S.W. A new concept of glucocorticosteroidaction: Effects on hyaluronidase Med-Hypotheses 1983; 10: 321-327.
6. Bok-S.W. Dem Leben mehr Jahre,oder den Jahren mehr Leben? Cythobiol. Revue 1983; 3 : 101-16.
7. Bok.S.W. Gene-manipulation in the view of a non-expert. Med-Hypotheses: Submitted jan 2002.
8. Bok-S.W. De fundamentele rol van de placenta postpartum. Ned. Tijdschr. Integrale Gen. 1988; 5: 99-102.

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